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Benedict and later Cahill
demonstrated the biochemical and nutritional derangements during simple,
unstressed starvation.
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1. Limited storage of CHO - main fuel during
fed state - 16-18 hours after NPO.
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2. Fuel changes to fat except for obligatory
CHO demands of brain, RBCs and renal parenchyma.
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3. Gluconeogenesis - primarily dependent on
protein sources - fat/glycerol contributing only 10%
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4. The GI tract as a metabolic organ shuttling
and utilizing glutamine.
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